کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504515 | 1536292 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila
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کلمات کلیدی
TPENZIPMTF-1Zinc-finger transcription factorZnTXFMRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهion transport - حمل و نقل یونendoplasmic reticulum - شبکه آندوپلاسمی Drosophila - مگس سرکهX-ray fluorescence microscopy - میکروسکوپ فلورسنت اشعه ایکسZinc homeostasis - هومئوستاز روی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila](/preview/png/5504515.png)
چکیده انگلیسی
The core zinc transport machinery is well conserved between invertebrates and mammals, with the vinegar fly Drosophila melanogaster having clear homologues of all major groups of mammalian ZIP and ZNT transport genes. Functional characterization of several of the fly genes has revealed functional conservation between related fly and mammalian zinc transporters in some but not all cases, indicating that Drosophila is a useful model for examining mammalian zinc metabolism. Furthermore, Drosophila research, sometimes quite serendipitously, has provided novel insights into the function of zinc transporters and into zinc-related pathologies, which are highlighted here. Finally, the future research potential of the fly in nutrient metabolism is explored, with reference to emerging experimental technologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 611, 1 December 2016, Pages 142-149
Journal: Archives of Biochemistry and Biophysics - Volume 611, 1 December 2016, Pages 142-149
نویسندگان
Christopher D. Richards, Richard Burke,