کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5505114 | 1400261 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages
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کلمات کلیدی
SREBP-1cScavenger receptor-ATNFSFLDLsDcR3SR-AoxLDLLTβRCPT-1ACAT1iNOSNF-κBACSAPCPPARαacyl-CoA synthetase - Acyl-CoA SynthetaseAtherosclerosis - آترواسکلروز(تصلب شریان)inflammation - التهاب( توروم) interleukin - اینترلوکینantigen presenting cell - سلولهای پردازنده آنتیژنinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییTumor necrosis factor superfamily - فاکتور نکروز تومور فوق فامیلیNuclear factor-kappa B - فاکتور هسته ای-کاپا Blymphotoxin β receptor - لنفو توکسین β گیرندهOxidized low-density lipoproteins - لیپوپروتئینهای کم تراکم اکسید شدهlow-density lipoproteins - لیپوپروتئینهای کم چگالیlight - نور Hyperlipidemia - هیپرلیپیدمیherpes virus entry mediator - ویروس تبخال ویروسیsterol regulatory element-binding protein-1c - پروتئین وابسته به استرول تنظیم کننده پروتئین-1cDecoy receptor 3 - گیرنده طعمه 3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Inflammation is critical for the progression of hyperlipidemia. Although the exact mechanism through which inflammation affects hyperlipidemia is not very clear, evidence suggests that the tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT)LIGHT might regulate lipid metabolism. In this study we investigated the expression of LIGHT in patients with different stages of coronary disease. The expression of lipid metabolism-related enzymes and inflammation-related proteins were further explored in oxidized low-density lipoproteins (oxLDL)-induced THP-1 macrophages. We found that LIGHT is highly expressed and companied with severe inflammations in patients with coronary disease. LIGHT significantly enhanced inflammation response in oxLDL-induced THP-1 macrophages. We further demonstrated that LIGHT markedly decreased the levels of lipolytic genes and increased the expressions of lipogenic genes in oxLDL-induced THP-1 macrophages. In addition, our results showed that LIGHT exerts its pro-inflammatory and pro-lipogenesis roles through activating nuclear factor-kappa B (NF-κB) signaling pathway. Taken together our study has demonstrated that LIGHT NF-κB-dependently exacerbates inflammation response and promotes lipid accumulation, and provided a new potential target for treatment of hyperlipidemia-related disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 490, Issue 3, 26 August 2017, Pages 732-738
Journal: Biochemical and Biophysical Research Communications - Volume 490, Issue 3, 26 August 2017, Pages 732-738
نویسندگان
Xiaomei Yuan, Yonglin Gu, Xiaoyu Lai, Qing Gu,