کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5506215 1400289 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Up-regulation of VEZT by small activating RNA inhibits the proliferation, invasion and migration of gastric cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Up-regulation of VEZT by small activating RNA inhibits the proliferation, invasion and migration of gastric cancer cells
چکیده انگلیسی
We identified the most effective saRNA via real-time PCR and Western blot. The selected saRNA inhibited the growth, invasion and migration of GC cells by specially reactivating VEZT. The real-time PCR and Western blot results showed that treatment with saRNA caused a significant up-regulation of VEZT, and an obvious decrease in the proliferative, invasive and migratory abilities; compared with the control groups (P < 0.01); furthermore, there were no significant differences among the control groups (P > 0.05). This phenomenon provides a theoretical basis for saRNA design and gene therapy for gastric cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 482, Issue 4, 22 January 2017, Pages 542-548
نویسندگان
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