کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550261 1557289 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of nonionic micelle-laden polysaccharide hydrogels for controlled delivery of hydrophobic drugs
ترجمه فارسی عنوان
طراحی هیدروژل های پلی ساکارید مزانشمی غیر مونواکسیدکربن برای تحویل کنترل داروهای هیدروفوب
کلمات کلیدی
ابر نقطه، نفوذ، پلی الکترولیت، ساختار / عملکرد رفتار فاز، مش
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The incorporation of micelle self-assembly in hydrogels has been used to produce self-healing materials, materials with tunable mechanical properties, and hydrophilic or hydrophobic drug delivery systems. However, little is known about the connection among formulation - structure - properties (particularly transport) in these systems. This connection is explored in alkyl ethoxylate micelle-laden gellan gum hydrogels used as delivery system for the hydrophobic drug dexamethasone. Phase behavior maps and rheological characterization of the micelle-laden hydrogels indicate that their properties are largely dominated by the concentration and cloud point (CP) of the alkyl ethoxylate nonionic surfactant. The sol-gel temperature of the hybrid hydrogels was found to be close to the CP of the surfactant, and their storage modulus (G') was found to increase with increasing surfactant concentration. A detailed analysis of the phase behavior maps, and evaluations of the mesh size of the hybrid hydrogels suggest a novel mechanism whereby micelles associate with gellan gum strands during high temperature hydration, hindering the double-helix assembly of the strands upon cooling. This increases the number of single strands and the density of physical cross-links, reducing the mesh size of the hydrogel. This mesh size reduction led to a decrease in the effective diffusion coefficient of micelles in the gel, and extended the release time of dexamethasone from 2 h in surfactant-free hydrogel to more than 2 days in the micelle-laden hydrogel.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 526, Issues 1–2, 30 June 2017, Pages 455-465
نویسندگان
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