کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5552501 | 1557947 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peroxisome proliferator-activated receptors as therapeutic targets for heart failure
ترجمه فارسی عنوان
گیرنده های فعال کننده پروکسیوم به عنوان اهداف درمانی برای نارسایی قلبی
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کلمات کلیدی
TNFDR1RXRNF-kBRetinoid X receptorPPARET-1Sirt1PGC-1αTZDs - TZD هاFatty acid - اسید چربendothelin-1 - اندوتلین-1Fatty acid oxidation - اکسیداسیون اسید چربcardiovascular disease - بیماری قلب و عروقیsilent information regulator 1 - تنظیم کننده اطلاعات خاموش 1thiazolidinediones - تیازولیدیدونهاTherapy - درمانFAO - فائوtumor necrosis factor - فاکتور نکروز تومورnuclear factor kappa-B - فاکتور هسته ای کاپا-Bheart failure - نارسایی قلبی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Heart failure (HF) is a common clinical syndrome that affects more than 23 million individuals worldwide. Despite the marked advances in its management, the mortality rates in HF patients have remained unacceptably high. Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription regulators, involved in the regulation of fatty acid and glucose metabolism. PPAR agonists are currently used for the treatment of type II diabetes mellitus and hyperlipidemia; however, their role as therapeutic agents for HF remains under investigation. Preclinical studies have shown that pharmacological modulation of PPARs can upregulate the expression of fatty acid oxidation genes in cardiomyocytes. Moreover, PPAR agonists were proven able to improve ventricular contractility and reduce cardiac remodelling in animal models through their anti-inflammatory, anti-oxidant, anti-fibrotic, and anti-apoptotic activities. Whether these effects can be replicated in humans is yet to be proven. This article reviews the interactions of PPARs with the pathophysiological mechanisms of HF and how the pharmacological modulation of these receptors can be of benefit for HF patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 95, November 2017, Pages 692-700
Journal: Biomedicine & Pharmacotherapy - Volume 95, November 2017, Pages 692-700
نویسندگان
Abdelrahman Ibrahim Abushouk, Mostafa Wanees Ahmed El-Husseny, Eshak I. Bahbah, Ahmed Elmaraezy, Aya Ashraf Ali, Asmaa Ashraf, Mohamed M. Abdel-Daim,