کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5556884 1560540 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress
چکیده انگلیسی

AimsOur previous finding demonstrates that major depressive disorder can mediate accelerated aging in rats. Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors. However, whether desipramine can rescue age-related phenotypes in depressed individuals is not understood. In the present study, we investigated the physiological function of desipramine on rescuing the age-related phenotypes in these animals.Main methodsThe rats were induced by chronic mild stress paradigm, and the depression-like behaviors of rats were detected by sucrose intake test, open field test (OFT) and forced swimming test (FST). Then the depressed rats were treated by desipramine.Key findingsDesipramine administration was effective in counteracting depression-like behaviors by increasing the sucrose solution intake, reducing the immobility time in the FST, and increasing total distance travelled and numbers of grid line crossed in the OFT. Moreover, desipramine treatment was able to reduce the oxidative damage to rat liver, and to increase the expression of telomerase reverse transcriptase (TERT), leading to correspondingly restored telomerase activity.SignificanceOur findings identify that one function of desipramine may partly be to rescue age-related phenotypes in depressed individuals induced by chronic stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 188, 1 November 2017, Pages 96-100
نویسندگان
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