کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557795 1560934 2017 62 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The double life of cardiac mesenchymal cells: Epimetabolic sensors and therapeutic assets for heart regeneration
ترجمه فارسی عنوان
زندگی دوگانه سلول های مزانشیمی قلبی: سنسورهای اپیدرمی و داروی درمانی برای بازسازی قلب
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی
Organ-specific mesenchymal cells naturally reside in the stroma, where they are exposed to some environmental variables affecting their biology and functions. Risk factors such as diabetes or aging influence their adaptive response. In these cases, permanent epigenetic modifications may be introduced in the cells with important consequences on their local homeostatic activity and therapeutic potential. Numerous results suggest that mesenchymal cells, virtually present in every organ, may contribute to tissue regeneration mostly by paracrine mechanisms. Intriguingly, the heart is emerging as a source of different cells, including pericytes, cardiac progenitors, and cardiac fibroblasts. According to phenotypic, functional, and molecular criteria, these should be classified as mesenchymal cells. Not surprisingly, in recent years, the attention on these cells as therapeutic tools has grown exponentially, although only very preliminary data have been obtained in clinical trials to date. In this review, we summarized the state of the art about the phenotypic features, functions, regenerative properties, and clinical applicability of mesenchymal cells, with a particular focus on those of cardiac origin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 171, March 2017, Pages 43-55
نویسندگان
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