کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559529 1403288 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholinergic system and cell proliferation
ترجمه فارسی عنوان
سیستم کولینرژیک و تکثیر سلولی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- The cholinergic system is present in most human cell types.
- Activation of acetylcholine receptors has a proliferative effect.
- The content of proteins of the cholinergic system is altered in many tumours.
- During apoptosis, acetylcholinesterase content increases.
- Acetylcholinesterase is involved in regulation of cell proliferation and apoptosis.

The cholinergic system, comprising acetylcholine, the proteins responsible for acetylcholine synthesis and release, acetylcholine receptors and cholinesterases, is expressed by most human cell types. Acetylcholine is a neurotransmitter, but also a local signalling molecule which regulates basic cell functions, and cholinergic responses are involved in cell proliferation and apoptosis. So, activation of nicotinic and muscarinic receptors has a proliferative and anti-apoptotic effect in many cells. The content of choline acetyltransferase, acetylcholine receptors and cholinesterases is altered in many tumours, and cholinesterase content correlates with patient survival in some cancers. During apoptosis, acetylcholinesterase is induced and appears in the nuclei. Acetylcholinesterase participates in the regulation of cell proliferation and apoptosis through hydrolysis of acetylcholine and by other catalytic and non catalytic mechanisms, in a variant-specific manner. This review gathers information on the role of cholinergic system and specially acetylcholinesterase in cell proliferation and apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 259, Part B, 25 November 2016, Pages 257-265
نویسندگان
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