کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589994 | 1570076 | 2017 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fas-activated serine/threonine kinase: Structure and function
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
Fas-activated serine/threonine kinase (FASTK) is a mitochondrial protein, which effectively binds to RNA and known to be a component of cytosolic RNA granules. FASTK is generally activated during Fas-mediated apoptosis by phosphorylating a nuclear RNA-binding protein TIA-1, and thus considered as an effector of apoptosis. A little report is available on the structural and functional aspects of this protein. In this review, we tried to provide comprehensive information on FASTK with a special attention to structure, function and interactions. Structurally, the C-terminal region is consists of two conserved kinase domains named, subdomain-1 and subdomain-2, which is involved in verities of functions and a putative RNA-binding domain (RAP domain). This review covers FASTK gene structure, expression and regulation, interactome and its biological function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Reports - Volume 8, September 2017, Pages 117-127
Journal: Gene Reports - Volume 8, September 2017, Pages 117-127
نویسندگان
Saurabha Srivastava, Sunayana Begum Syed, Vijay Kumar, Asimul Islam, Faizan Ahmad, Md. Imtaiyaz Hassan,