کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622623 1406183 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleMediterranean diet and preserved brain structural connectivity in older subjects
ترجمه فارسی عنوان
رژیم غذای ویژه و مرطوب نگهدارنده مغزی در افراد مسن تر از افراد مسن نگهداری می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

IntroductionThe Mediterranean diet (MeDi) has been related to a lower risk of Alzheimer's disease; yet, the underlying mechanisms are unknown. We hypothesized that protection against neurodegeneration would translate into higher gray matter volumes, whereas a specific association with preserved white matter microstructure would suggest alternative mechanisms (e.g., vascular pathways).MethodsWe included 146 participants from the Bordeaux Three-City study nondemented when they completed a dietary questionnaire and who underwent a 3-T magnetic resonance imaging at an average of 9 years later, including diffusion tensor imaging.ResultsIn multivariate voxel-by-voxel analyses, adherence to the MeDi was significantly associated with preserved white matter microstructure in extensive areas, a gain in structural connectivity that was related to strong cognitive benefits. In contrast, we found no relation with gray matter volumes.DiscussionThe MeDi appears to benefit brain health through preservation of structural connectivity. Potential mediation by a favorable impact on brain vasculature deserves further research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 9, September 2015, Pages 1023-1031
نویسندگان
, , , , , , , , , , , ,