کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5625771 | 1579319 | 2017 | 9 صفحه PDF | دانلود رایگان |
ObjectiveThis study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants.DesignCross-sectional study.ParticipantsWe included 111 older adults (80 with LLD and 31 comparison participants) in this study.MeasurementA panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants. We conducted a principal component analysis to create the SASP index based on individual weights of each of protein.ResultsParticipants with LLD showed a significantly increased SASP index compared with comparison participants, after controlling for age, depressive symptoms, medical comorbidity (CIRS-G) scores, sex, and cognitive performance (F(1,98)â=â7.3, pâ=â0.008). Correlation analyses revealed that the SASP index was positively correlated with age (râ=â0.2, pâ=â0.03) and CIRS score (râ=â0.27, pâ=â0.005), and negatively correlated with information processing speed (râ=ââ0.34, pâ=â0.001), executive function (râ=ââ0.27, pâ=â0.004) and global cognitive performance (râ=ââ0.28, pâ=â0.007).ConclusionsTo the best of our knowledge, this is the first study to show that a set of proteins (i.e., SASP index) primarily associated with cellular aging is abnormally regulated and elevated in LLD. These results suggest that individuals with LLD display enhanced aging-related molecular patterns that are associated with higher medical comorbidity and worse cognitive function. Finally, we provide a set of proteins that can serve as potential therapeutic targets and biomarkers to monitor the effects of therapeutic or preventative interventions in LLD.
Journal: The American Journal of Geriatric Psychiatry - Volume 25, Issue 1, January 2017, Pages 64-72