کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5628091 | 1406365 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Declarative long-term memory and the mesial temporal lobe: Insights from a 5-year postsurgery follow-up study on refractory temporal lobe epilepsy
ترجمه فارسی عنوان
حافظه طولانی مدت اعلام شده و لوب مریضی زمان: بررسی های انجام شده از یک مطالعه 5 ساله پس از عمل جراحی بر روی صرع لوب مقاوم به نور
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کلمات کلیدی
left temporal lobe epilepsyLTMLTLETLEPALAEDsBDIhippocampal sclerosis - اسکلروز هیپوکامپ Epilepsy - بیماری صرعfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیMemory - حافظهlong-term memory - حافظه بلندمدتantiepileptic drugs - داروهای ضدصرع temporal lobe epilepsy - صرع لوب تمپورالright temporal lobe epilepsy - صرع لوب صرع صحیحSurgery - عمل جراحیtemporal lobe - لوب گیجگاهی، لوب تمپورالHippocampus - هیپوکامپ Beck Depression Inventory - پرسشنامه افسردگی بک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
It is largely recognized that the mesial temporal lobe and its substructure support declarative long-term memory (LTM). So far, different theories have been suggested, and the organization of declarative verbal LTM in the brain is still a matter of debate. In the current study, we retrospectively selected 151 right-handed patients with temporal lobe epilepsy with and without hippocampal sclerosis, with a homogeneous (seizure-free) clinical outcome. We analyzed verbal memory performance within a normalized scores context, by means of prose recall and word paired-associate learning tasks. Patients were tested at presurgical baseline, 6Â months, 2 and 5Â years after anteromesial temporal lobe surgery, using parallel versions of the neuropsychological tests. Our main finding revealed a key involvement of the left temporal lobe and, in particular, of the left hippocampus in prose recall rather than word paired-associate task. We also confirmed that shorter duration of epilepsy, younger age, and withdrawal of antiepileptic drugs would predict a better memory outcome. When individual memory performance was taken into account, data showed that females affected by left temporal lobe epilepsy for longer duration were more at risk of presenting a clinically pathologic LTM at 5Â years after surgery. Taken together, these findings shed new light on verbal declarative memory in the mesial temporal lobe and on the behavioral signature of the functional reorganization after the surgical treatment of temporal lobe epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 64, Part A, November 2016, Pages 102-109
Journal: Epilepsy & Behavior - Volume 64, Part A, November 2016, Pages 102-109
نویسندگان
Gerardo Salvato, Pina Scarpa, Stefano Francione, Roberto Mai, Laura Tassi, Elisa Scarano, Giorgio Lo Russo, Gabriella Bottini,