کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5648334 1587497 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ocular pyoderma gangrenosum: A systematic review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Ocular pyoderma gangrenosum: A systematic review
چکیده انگلیسی

BackgroundPyoderma gangrenosum (PG) is a rare, ulcerative cutaneous disorder. Ophthalmic involvement in PG is atypical, but can have devastating consequences.ObjectiveWe sought to characterize ocular PG to allow for earlier diagnosis and therapy. To our knowledge, this is the first systematic review summarizing this clinical variant.MethodsA systematic review was conducted using PubMed and Web of Science. Data were extracted and studies were qualitatively assessed and analyzed.ResultsWe identified all 34 cases of PG involving the eye and periorbital area, and categorized them into 4 different subtypes. Common presenting signs include ulceration, peripheral ulcerative keratitis, and decreased visual acuity. Although it is often difficult to biopsy ocular PG, histologic features are nonspecific. Combined therapy using corticosteroids and further surgical reconstruction as needed is the mainstay of treatment. Cases of the eye/orbit in particular should be treated aggressively, as these are more likely to relapse compared with cases of the periorbital area.LimitationsUse of case reports, paucity of ocular PG cases, and heterogeneity of studies are limitations.ConclusionPG should be considered in the differential diagnosis of ulceration of ocular/periocular tissues. An aggressive, early, multimodal treatment strategy should be used to prevent relapse, especially in cases of the eye/orbit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 76, Issue 3, March 2017, Pages 512-518
نویسندگان
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