کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5664684 | 1407717 | 2016 | 6 صفحه PDF | دانلود رایگان |
BackgroundPlatelet suspensions (PSs) are stored at room temperature. However, recent reports show that PSs stored at 4â°C possess superior hemostatic properties. We compared the viabilities and thrombin generation capacities of PSs stored either at 4â°C or 22â°C hours.Materials and MethodsTwenty units of apheresis derived platelets (ADPs) from 20 male donors and 20 units of random platelet suspensions (RPSs) from another 20 male donors were obtained. Half of the ADPs and half of the RPSs (10 units/per group) were stored at 4â°C, the other halves of ADPs and RPSs (10 units/per group) were stored in agitators at 22â°C for 48 hours. The flow cytometric viability tests and thrombin generation tests of the PSs were assessed.ResultsThe viabilities of both ADPs and RPSs group platelets, stored either at 4â°C or 22â°C for 48 hours, were not statistically significantly different. The ADPs and RPSs stored at 4â°C generated significantly higher peak thrombin levels than the platelets stored at 22â°C. Moreover, the ADPs group stored at 4â°C showed significantly shorter time to thrombin generation and reach peak levels.ConclusionThe PSs stored at 4â°C showed higher and faster thrombin generation capacities than the room temperature PSs. Given the superior hemostatic properties of refrigerated platelets, creating different storage temperature capabilities for specific transfusion purposes may be a prudent approach, especially for improving the outcome of bleeding trauma casualties.
Journal: Transfusion and Apheresis Science - Volume 55, Issue 3, December 2016, Pages 323-328