کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5674080 | 1593683 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Akkermansia muciniphila and its role in regulating host functions
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کلمات کلیدی
DSSMGSFODMAPT2DHFDT-RFLPqPCRAkkermansia muciniphilaLPSQuantitative PCR - PCR کمیMetabolic disorder - اختلال متابولیکimmunoglobulin A - ایمونوگلوبولین AIgA - ایمونوگلوبولین IgA Inflammatory bowel disease - بیماریهای التهابی رودهType 2 diabetes - دیابت نوع 2High fat diet - رژیم غذایی با چربی بالاDextran sulfate sodium - سولفات سدیم دکسترانfluorescent in situ hybridization - فلورسنت در محل hybridizationlipopolysaccharide - لیپوپلی ساکاریدFish - ماهیTerminal-restriction fragment length polymorphism - پلیمورفیسم طول قطعه محدودیت ترمینال
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
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چکیده انگلیسی
Akkermansia muciniphila is an intestinal bacterium that was isolated a decade ago from a human fecal sample. Its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells. Although it was isolated quite recently, it has rapidly raised significant interest as A. muciniphila is the only cultivated intestinal representative of the Verrucomicrobia, one of the few phyla in the human gut that can be easily detected in phylogenetic and metagenome analyses. There has also been a growing interest in A. muciniphila, due to its association with health in animals and humans. Notably, reduced levels of A. muciniphila have been observed in patients with inflammatory bowel diseases (mainly ulcerative colitis) and metabolic disorders, which suggests it may have potential anti-inflammatory properties. The aims of this review are to summarize the existing data on the intestinal distribution of A. muciniphila in health and disease, to provide insight into its ecology and its role in founding microbial networks at the mucosal interface, as well as to discuss recent research on its role in regulating host functions that are disturbed in various diseases, with a specific focus on metabolic disorders in both animals and humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 106, May 2017, Pages 171-181
Journal: Microbial Pathogenesis - Volume 106, May 2017, Pages 171-181
نویسندگان
Muriel Derrien, Clara Belzer, Willem M. de Vos,