کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5720936 1411336 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice
چکیده انگلیسی

BackgroundNeural networks that regulate binge eating remain to be identified, and effective treatments for binge eating are limited.MethodsWe combined neuroanatomic, pharmacologic, electrophysiological, Cre-lox, and chemogenetic approaches to investigate the functions of 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) expressed by dopamine (DA) neurons in the regulation of binge-like eating behavior in mice.ResultsWe showed that 5-HT stimulates DA neural activity through a 5-HT2CR-mediated mechanism, and activation of this midbrain 5-HT→DA neural circuit effectively inhibits binge-like eating behavior in mice. Notably, 5-HT medications, including fluoxetine, d-fenfluramine, and lorcaserin (a selective 5-HT2CR agonist), act on 5-HT2CRs expressed by DA neurons to inhibit binge-like eating in mice.ConclusionsWe identified the 5-HT2CR population in DA neurons as one potential target for antibinge therapies, and provided preclinical evidence that 5-HT2CR agonists could be used to treat binge eating.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 81, Issue 9, 1 May 2017, Pages 737-747
نویسندگان
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