کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5820188 | 1557377 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficacy of edelfosine lipid nanoparticles in breast cancer cells
ترجمه فارسی عنوان
اثربخشی نانوذرات لیپیدی ادرالفسین در سلولهای سرطانی پستان
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کلمات کلیدی
PDIIC50MCF7MCLEdelfosine - Edelfosinalkylphospholipids - آلکال فسفولیپیدهاEPR effect - اثر EPRAlps - رشته کوههای آلپ، کوه های آلپBreast cancer - سرطان پستانpolydispersity index - شاخص پلییدریزاییinhibitory concentration 50 - غلظت مهاری 50Mantle cell lymphoma - لنفوم سلول انسانیLipid nanoparticles - نانوذرات لیپیدیEnhanced permeability and retention effect - نفوذپذیری پیشرفته و اثر احتباسPropidium iodide - پروتئین یدید
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
چکیده انگلیسی
Breast cancer is a heterogeneous group of neoplasms predominantly originating in the terminal duct lobular units. It represents the leading cause of cancer death in women and the survival frequencies for patients at advanced stages of the disease remain low. New treatment options need to be researched to improve these rates. The anti-tumor ether lipid edelfosine (ET) is the prototype of a novel generation of promising anticancer drugs. However, it presents several drawbacks for its use in cancer therapy, including gastrointestinal and hemolytic toxicity and low oral bioavailability. To overcome these obstacles, ET was encapsulated in Precirol ATO 5 lipid nanoparticles (ET-LN), and its anti-tumor potential was in vitro tested in breast cancer. The formulated ET-LN were more effective in inhibiting cell proliferation and notably decreased cell viability, showing that the cytotoxic effect of ET was considerably enhanced when ET was encapsulated. In addition, ET and ET-LN were able to promote cell cycle arrest at G1 phase. Moreover, although both treatments provoked an apoptotic effect in a time-dependent manner, such anti-tumor effects were noticeably improved with ET-LN treatment. Therefore, our results indicate that encapsulating ET in LN played an essential role in improving the efficacy of the drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 454, Issue 2, 1 October 2013, Pages 720-726
Journal: International Journal of Pharmaceutics - Volume 454, Issue 2, 1 October 2013, Pages 720-726
نویسندگان
MarÃa Ángela Aznar, Beatriz Lasa-SaracÃbar, Ander Estella-Hermoso de Mendoza, MarÃa José Blanco-Prieto,