کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5821332 1557439 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of acetaminophen's solubility in poly(ethylene oxide) by rheological, thermal and microscopic methods
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Determination of acetaminophen's solubility in poly(ethylene oxide) by rheological, thermal and microscopic methods
چکیده انگلیسی

A drug's solubility in a polymeric excipient is an important parameter that dictates the process window of hot-melt extrusion (HME) and product stability during storage. However, it is rather challenging to experimentally determine the solubility and there is very few published work in this field. In this study, the solubility of a model drug acetaminophen (APAP) in a pharmaceutical grade polymer poly(ethylene oxide) (PEO) at HME processing temperature was measured utilizing rheological analysis, hot-stage microscopy and differential scanning calorimetry (DSC). The results from three methods were consistent and the solubility was found to increase from 14% at 80 °C to 41% at 140 °C. The apparent drug solubility at room temperature was estimated to be less than 10% through glass transition temperature (Tg) measurement using DSC and dynamic mechanical thermal analysis (DMTA). A “phase diagram” was constructed based on the experimental data and could be explored to design the HME process and formulation. Very few assumptions were made in the experimental study and result analysis, and the methods described here can be applied to investigate other drug-polymer systems to obtain the important thermodynamic data.

The solubility of acetaminophen (APAP) in poly(ethylene oxide) (PEO) at different temperatures was measured utilizing rheological analysis, hot-stage microscopy and differential scanning calorimetry (DSC).85

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 403, Issues 1–2, 17 January 2011, Pages 83-89
نویسندگان
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