کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5821615 | 1557811 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection
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کلمات کلیدی
PRRRSVinflammation - التهاب( توروم) PVM - تاریخCytokines - سیتوکین هاLactobacillus plantarum - لاکتوباسیلوسRespiratory syncytial virus - ویروس سنسیتیال تنفسیPneumonia virus of mice - ویروس پنومونی موشProbiotic - پروبیوتیکPneumovirus - پنومونی ویروسpattern recognition receptors - گیرنده های تشخیص الگوPRR, Pattern recognition receptor - گیرنده های شناسایی الگو
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pattern recognition receptors (PRRs) engage microbial components in the lung, although their role in providing primary host defense against respiratory virus infection is not fully understood. We have previously shown that Gram-positive Lactobacillus plantarum (Lp) administered to the respiratory tract promotes full and sustained protection in response to an otherwise lethal mouse pneumovirus (PVM) infection, a robust example of heterologous immunity. While Lp engages PRRs TLR2 and NOD2 in ex vivo signaling assays, we found that Lp-mediated protection was unimpaired in single gene-deleted TLR2â/â and NOD2â/â mice. Here we demonstrate substantial loss of Lp-mediated protection in a double gene-deleted NOD2â/âTLR2â/â strain. Furthermore, we demonstrate protection against PVM infection by administration of the bi-functional NOD2-TLR2 agonist, CL-429. The bi-functional NOD2-TLR2 ligand CL-429 not only suppresses virus-induced inflammation, it is significantly more effective at preventing lethal infection than equivalent amounts of mono-molecular TLR2 and NOD2 agonists. Interestingly, and in contrast to biochemical NOD2 and/or TLR2 agonists, Lp remained capable of eliciting primary proinflammatory responses from NOD2â/âTLR2â/â mice in vivo and from alveolar macrophages challenged ex vivo. Taken together, we conclude that coordinate engagement of NOD2 and TLR2 constitutes a key step in the genesis of Lp-mediated protection from a lethal respiratory virus infection, and represents a critical target for modulation of virus-induced inflammatory pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 132, August 2016, Pages 131-140
Journal: Antiviral Research - Volume 132, August 2016, Pages 131-140
نویسندگان
Tyler A. Rice, Todd A. Brenner, Caroline M. Percopo, Michelle Ma, Jesse D. Keicher, Joseph B. Domachowske, Helene F. Rosenberg,