EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

► EPs® 7630 has a robust effect against multiple different IAV strains in vitro. ► EPs® 7630 inhibits an early step of infection and acts on virus and host cell. ► Prodelphinidins constitute the active antiviral principle. ► Anti-influenza efficacy goes in parallel to the prodelphinidin chain length. ► EPs® 7630 administered by inhalation protects mice against a lethal virus challenge.