Decreased expression of small-conductance Ca2Â +-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation

Our results demonstrated that SK1 and SK2 are involved in electrical remodeling of cAF. SK1-3 and IK,Ca do not display the inter-atrial differential distribution in SR or cAF. These findings provide a new insight into mechanisms of electrical remodeling of human cAF.