کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5843998 | 1127493 | 2014 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The purinergic neurotransmitter revisited: A single substance or multiple players?
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کلمات کلیدی
NPPSNAP-25NMNSNARETTXENSNGFADPEFsNANCFLDADPRPDGFRAMPIJPApnASMCEJPPurinergic neurotransmissionADP-riboseICCEJCsoluble N-ethylmaleimide sensitive factor attachment protein receptorAdenosine - آدنوزینadenosine 5′-triphosphate - آدنوزین 5'-تری فسفاتadenosine 5′-diphosphate - آدنوزین 5'-دی فسفاتadenosine 5′-monophosphate - آدنوزین 5'-مونوفسفرهATP - آدنوزین تری فسفات یا ATPACh - آهAcetylcholine - استیل کولینtetrodotoxin - تترو دوتوکسین Electrical field stimulation - تحریک الکتریکی میدانCNS - دستگاه عصبی مرکزیGastrointestinal - دستگاه گوارشdiadenosine polyphosphates - دی آمنوزین پلی فسفاتSmooth muscle cell - سلول عضلانی صافinterstitial cells of Cajal - سلولهای بینابینی CajalNervous system - سیستم عصبیenteric nervous system - سیستم عصبی روده ایcentral nervous system - سیستم عصبی مرکزیgap junction - فاصله ی شکافnerve growth factor - فاکتور رشد عصبNAD - نادانnorepinephrine - نوراپی نفرینNitric oxide - نیتریک اکسیدnicotinamide mononucleotide - نیکوتین آمید مونونوکلئوتیدNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدinhibitory junction potential - پتانسیل اتصال مهار کنندهexcitatory junction potential - پتانسیل اتصال هیجانیsynaptosomal-associated protein 25 - پروتئین مرتبط با سیناپتوزوموم 25high-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراplatelet-derived growth factor receptor - گیرنده عامل فاکتور رشد یافته پلاکت
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
The past half century has witnessed tremendous advances in our understanding of extracellular purinergic signaling pathways. Purinergic neurotransmission, in particular, has emerged as a key contributor in the efficient control mechanisms in the nervous system. The identity of the purine neurotransmitter, however, remains controversial. Identifying it is difficult because purines are present in all cell types, have a large variety of cell sources, and are released via numerous pathways. Moreover, studies on purinergic neurotransmission have relied heavily on indirect measurements of integrated postjunctional responses that do not provide direct information for neurotransmitter identity. This paper discusses experimental support for adenosine 5â²-triphosphate (ATP) as a neurotransmitter and recent evidence for possible contribution of other purines, in addition to or instead of ATP, in chemical neurotransmission in the peripheral, enteric and central nervous systems. Sites of release and action of purines in model systems such as vas deferens, blood vessels, urinary bladder and chromaffin cells are discussed. This is preceded by a brief discussion of studies demonstrating storage of purines in synaptic vesicles. We examine recent evidence for cell type targets (e.g., smooth muscle cells, interstitial cells, neurons and glia) for purine neurotransmitters in different systems. This is followed by brief discussion of mechanisms of terminating the action of purine neurotransmitters, including extracellular nucleotide hydrolysis and possible salvage and reuptake in the cell. The significance of direct neurotransmitter release measurements is highlighted. Possibilities for involvement of multiple purines (e.g., ATP, ADP, NAD+, ADP-ribose, adenosine, and diadenosine polyphosphates) in neurotransmission are considered throughout.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 144, Issue 2, November 2014, Pages 162-191
Journal: Pharmacology & Therapeutics - Volume 144, Issue 2, November 2014, Pages 162-191
نویسندگان
Violeta N. Mutafova-Yambolieva, Leonie Durnin,