کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844265 | 1561030 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heart rate variability in major depressive disorder and after antidepressant treatment with agomelatine and paroxetine: Findings from the Taiwan Study of Depression and Anxiety (TAISDA)
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کلمات کلیدی
TCAs5-HT2CSSRIsHAM-DMDDBAIBDIDBPSBPHAM-AVLFMT1MT2Schedule of Affective Disorder and Schizophrenia-LifetimeHRV - ENGAgomelatine - آگوملاتینMajor depressive disorder - اختلال افسردگی عمدهMANOVA - انتخاب کنیدcardiovascular disease - بیماری قلب و عروقیmultivariate analysis of variance - تجزیه و تحلیل چند متغیره واریانسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetricyclic antidepressants - داروهای ضد افسردگی سه حلقه ایCVD - رسوب دهی شیمیایی بخار body mass index - شاخص توده بدنBMI - شاخص توده بدنیCardiac autonomic function - عملکرد اتواییک قلبdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکhigh-frequency power - قدرت فرکانس بالاlow-frequency power - قدرت فرکانس پایینHamilton anxiety rating scale - مقیاس درجه اضطراب همیلتونHamilton Depression Rating Scale - مقیاس رتبه بندی افسردگی همیلتونselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیheart rate variability - نوسان ضربان قلبParoxetine - پاروکستینBeck Anxiety Inventory - پرسشنامه اضطراب BeckBeck Depression Inventory - پرسشنامه افسردگی بک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Evidence from previous studies suggests that heart rate variability (HRV) is reduced in major depressive disorder (MDD). However, whether this reduction is attributable to the disorder per se or to medication, since antidepressants may also affect HRV, is still debated. There is a dearth of information regarding the effects of agomelatine, a novel antidepressant, on HRV. Here, we investigated whether HRV is reduced in MDD and compared the effects of agomelatine and paroxetine on HRV. We recruited 618 physically healthy unmedicated patients with MDD and 506 healthy volunteers aged 20-65 years. Frequency-domain measures of resting HRV were obtained at the time of enrollment for all participants. For patients with MDD, these measures were obtained again after 6 weeks of either agomelatine or paroxetine monotherapy. Compared with healthy subjects, unmedicated patients with MDD exhibited significantly lower variance (total HRV), low frequency (LF), and high frequency (HF) HRV, and a higher LF/HF ratio. Depression severity independently contributed to decreased HRV and vagal tone. Fifty-six patients completed the open-label trial (n = 29 for agomelatine, n = 27 for paroxetine). Between-group analyses showed a significant group-by-time interaction for LF-HRV and HF-HRV, driven by increases in LF-HRV and HF-HRV only after agomelatine treatment. Within the paroxetine-treated group, there were no significant changes in mean R-R intervals or any HRV indices. We therefore concluded that MDD is associated with reduced HRV, which is inversely related to depression severity. Compared with paroxetine, agomelatine has a more vagotonic effect, suggesting greater cardiovascular safety. Clinicians should consider HRV effects while selecting antidepressants especially for depressed patients who already have decreased cardiac vagal tone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 64, 4 January 2016, Pages 60-67
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 64, 4 January 2016, Pages 60-67
نویسندگان
Ta-Chuan Yeh, Lien-Cheng Kao, Nian-Sheng Tzeng, Terry B.J. Kuo, San-Yuan Huang, Chuan-Chia Chang, Hsin-An Chang,