کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844318 | 1561040 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nucleus accumbens core and shell inactivation differentially affects impulsive behaviours in rats
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کلمات کلیدی
NACITIVTAMPFCNMDA5-CSRTTSSRTAP-5N-methyl-d-aspartic acidPavlovian-instrumental transfermRNAGABAA agonistDRLPBSFCMT-maze - T-مازAttention-Deficit/Hyperactivity Disorder - اختلال نقص توجه / بیش فعالیgamma-aminobutyric acid - اسید گاما آمینو بوتیریکForced choice - انتخاب اجباریADHD - بیشفعالیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDecision-making - تصمیم گیریstandard error of the mean - خطای استاندارد میانگینDopamine - دوپامینlight-emitting diode - دیود نورافشانmessenger ribonucleic acid - رسوب ریبونوکلئیک اسیدLED - رهبریstop-signal reaction time - زمان واکنش سیگنال توقفintertrial interval - فاصله بین فضاییmedial prefrontal cortex - قشر غده پروسترولPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریStimulus duration - مدت زمان تحریکSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbens5-choice serial reaction time task - کار 5 بار واکنش سریال واکنشImpulse control - کنترل ضربهGABA - گاباPit - گودال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Impulsivity is a multifactorial phenomenon, determined by deficits in decision-making (impulsive choice) and impulse control (impulsive action). Recent findings indicate that impulsive behaviour is not only top-down controlled by cortical areas, but also modulated at subcortical level. The nucleus accumbens (NAc) might be a key substrate in cortico-limbic-striatal circuits involved in impulsive behaviour. Dissociable effects of the NAc subregions in various behavioural paradigms point to a potential functional distinction between NAc core and shell concerning different types of impulsivity. The present study used reversible inactivation of the rats' NAc core and shell via bilateral microinfusion of the GABAA receptor agonist muscimol (0.05 μg/0.3 μl) and fluorophore-conjugated muscimol (FCM, 0.27 μg/0.3 μl) in order to study their contribution to different aspects of impulse control in a 5-choice serial reaction time task (5-CSRTT) and impulsive choice in a delay-based decision-making T-maze task. Acute inactivation of NAc core as well as shell by muscimol increased impulsive choice, with higher impairments of the rats' waiting capacity in the T-maze following core injections compared to shell. Intra-NAc shell infusion of muscimol also induced specific impulse control deficits in the 5-CSRTT, while deactivation of the core caused severe general impairments in task performance. FCM did not affect animal behaviour. Our findings reveal clear involvement of NAc shell in both forms of impulsivity. Both subareas play a key role in the regulation of impulsive decision-making, but show functional dichotomy regarding impulse control with the core being more implicated in motivational and motor aspects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 54, 3 October 2014, Pages 31-42
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 54, 3 October 2014, Pages 31-42
نویسندگان
Malte Feja, Linda Hayn, Michael Koch,