کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844411 | 1561039 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recent advances with a novel model organism: Alcohol tolerance and sensitization in zebrafish (Danio rerio)
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کلمات کلیدی
qPCRCPPALDH2ADH5HIAADOPACSLCQTL3, 4-dihydroxyphenylacetic acid - 3، 4-دی هیدروکسی فنیل اسیدهای اسید5-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدAChE - آهیEthanol - اتانولAcetaldehyde dehydrogenase - استالدئید دهیدروژنازAcetylcholinesterase - استیل کولین استرازgamma-aminobutyric acid - اسید گاما آمینو بوتیریکAlcohol addiction - اعتیاد به الکلAlcohol dehydrogenase - الکل دهیدروژنازAlcohol tolerance - تحمل الکلconditioned place preference - ترجیح محل موظف استQuantitative trait loci - تعداد صفات صفاتsolute carrier - حامل رقیبBehavioral phenotyping - فنوتیپی رفتاریwild-type - نوع وحشیquantitative polymerase chain reaction - واکنش زنجیره ای پلیمراز کمیHigh pressure liquid chromatography - کروماتوگرافی مایع با فشار بالاHPLC - کروماتوگرافی مایعی کاراGABA - گاباZebrafish - گورخرماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alcohol abuse and dependence are a rapidly growing problem with few treatment options available. The zebrafish has become a popular animal model for behavioral neuroscience. This species may be appropriate for investigating the effects of alcohol on the vertebrate brain. In the current review, we examine the literature by discussing how alcohol alters behavior in zebrafish and how it may affect biological correlates. We focus on two phenomena that are often examined in the context of alcohol-induced neuroplasticity. Alcohol tolerance (a progressive decrease in the effect of alcohol over time) is often observed following continuous (chronic) exposure to low concentrations of alcohol. Alcohol sensitization also called reverse tolerance (a progressive increase in the effect of alcohol over time) is often observed following repeated discrete exposures to higher concentrations of alcohol. These two phenomena may underlie the development and maintenance of alcohol addiction. The phenotypical characterization of these responses in zebrafish may be the first important steps in establishing this species as a tool for the analysis of the molecular and neurobiological mechanisms underlying human alcohol addiction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 55, 3 December 2014, Pages 87-93
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 55, 3 December 2014, Pages 87-93
نویسندگان
Steven Tran, Robert Gerlai,