کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844530 | 1561046 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term impacts of adolescent risperidone treatment on behavioral responsiveness to olanzapine and clozapine in adulthood
ترجمه فارسی عنوان
اثرات درازمدت درمان ریزپریدون نوجوان بر پاسخ رفتاری به الانزاپین و کلوزاپین در بزرگسالی
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کلمات کلیدی
RISFDACLZPCPOLZPPIPFCgamma amino butyric acid - اسید گاما آمینو بوتیریکOlanzapine - الانزاپینBrdU - بروموداکسی اوریدینAdolescence - بلوغ، دوره جوانی، نوجوانیSensitization - حساسیتDopamine - دوپامینRisperidone - ریسپریدون subcutaneously - زیر جلدیFood and Drug Administration - سازمان غذا و داروPhencyclidine - فن سیکلیدین، گرد فرشتهprefrontal cortex - قشر prefrontalCAR - ماشینunconditioned stimulus - محرک بی قید و شرطconditioned stimulus - محرک شرطیPrepulse inhibition - مهار پیش قاعدگیveh - وایVehicle - وسیله نقلیهConditioned avoidance response - پاسخ اجتناب مطبوعPostnatal - پس از زایمانclozapine - کلوزاپین GABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
This preclinical study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response to olanzapine and clozapine in adulthood. Antipsychotic effect was indexed by a drug's suppressive effect on avoidance responding in a rat conditioned avoidance response (CAR) model. Male adolescent Sprague-Dawley rats were first treated with risperidone (1.0Â mg/kg, sc) or sterile water and tested in the CAR model for 5 consecutive days from postnatal days P 40 to 44. After they became adults (~Â P 80-84), they were switched to olanzapine (0.5Â mg/kg, sc), clozapine (5.0Â mg/kg, sc) or vehicle treatment and tested for avoidance for 5Â days. During the adolescent period, repeated risperidone treatment produced a persistent inhibition of avoidance response. Throughout the 5Â days of adulthood drug testing, rats previously treated with risperidone in adolescence made significantly fewer avoidance responses than the vehicle ones when they all were switched to olanzapine, indicating a risperidone-induced enhancement of behavioral sensitivity to olanzapine. In contrast, when switched to clozapine, rats previously treated with risperidone made significantly more avoidance responses than the vehicle rats, indicating a risperidone-induced decrease of behavioral sensitivity to clozapine. Performance in the prepulse inhibition of acoustic startle response in adulthood was not altered by adolescent risperidone treatment. Collectively, adolescent risperidone exposure induced a long-term change in behavioral sensitivity to other atypical antipsychotic drugs, with the specific direction of change (i.e., increase or decrease) dependent on the drug to be switched to. These long-lasting changes are likely mediated by drug-induced neuroplastic changes and may also have significant clinical implications for antipsychotic treatment of chronic patients with an early onset of psychotic symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 177-185
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 177-185
نویسندگان
Jing Qiao, Qinglin Zhang, Ming Li,