کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844548 | 1561046 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus
ترجمه فارسی عنوان
تشنج الکتروکوهانس باعث ترومبوسپوندن 1 در هیپوکامپ موش بالغ می شود
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کلمات کلیدی
ADAMTS-1SynaptogenesisEGFBCAMDDCOMPTSP-1TSPSPARCGAPDHGFAPECTSDSECs - EC هاMajor depressive disorder - اختلال افسردگی عمدهmood disorder - اختلال خلقیbicinchoninic acid - بیسینکنینیک اسیدThrombospondin - ترومبوزپوندینElectroconvulsive seizure - تشنج الکتریکیElectroconvulsive therapy - درمان با ضربه الکتریکی تشنجآور، الکتروشوک درمانیsodium dodecyl sulfate - سدیم دودسیل سولفاتepidermal growth factor - عامل رشد اپیدرمیGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالsecreted protein acidic and rich in cysteine - پروتئین اسیدی و غنی از سیتین را ترشح می کندCartilage oligomeric matrix protein - پروتئین ماتریکس oligomeric غضروفیglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازGlia - یاختههای گلیال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Synaptic dysfunction has recently gained attention for its involvement in mood disorders. Electroconvulsive therapy (ECT) possibly plays a role in synaptic repair. However, the underlying mechanisms remain uncertain. Thrombospondin-1 (TSP-1), a member of the TSP family, is reported to be secreted by astrocytes and to regulate synaptogenesis. We investigated the effects of electroconvulsive seizure (ECS) on the expression of TSPs in the adult rat hippocampus. Single and repeated ECS significantly increased TSP-1 mRNA expression after 2 h and returned to sham levels at 24 h. Conversely, the TSP-2 and -4 mRNA levels did not change. Only repeated ECS induced TSP-1 proteins. ECS also induced glial fibrillary acidic protein (GFAP) expression. The GFAP expression occurred later than the TSP-1 mRNA expression following single ECS; however, it occurred earlier and was more persistent following repeated ECS. ECS had no effect on the α2δ-1 or neuroligin-1 expressions, both of which are TSP-1 receptors. Furthermore, chronic treatment with antidepressants did not induce the expression of TSP-1 or GFAP. These findings suggest that repeated ECS, but not chronic treatment with antidepressants, induces TSP-1 expression partially via the activation of astrocytes. Therefore, TSP-1 is possibly involved in the synaptogenic effects of ECS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 236-244
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 236-244
نویسندگان
Mami Okada-Tsuchioka, Masahiro Segawa, Naoto Kajitani, Kazue Hisaoka-Nakashima, Chiyo Shibasaki, Shigeru Morinobu, Minoru Takebayashi,