Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis

► Orbitofrontal sylcogyral folding pattern distributions are altered in psychosis. ► Type II pattern in both hemispheres led to a five-fold risk of psychosis. ► Psychosis patients have fewer intermediate orbital sulci. ► Orbitofrontal sulci thickness was reduced in patients and related to pattern Type I. ► Patients with three intermediate orbital sulci had a higher mean gyrification index.