کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5844696 1561048 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Longitudinal associations between mismatch negativity and disability in early schizophrenia- and affective-spectrum disorders
ترجمه فارسی عنوان
ارتباط طولی بین منفی و عدم توانایی ناسازگاری در اختلالات اسکیزوفرنی اولیه و اختلالات طیف عاطفی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
This study provides some evidence of the predictive utility of MMN at the early stages of schizophrenia- and affective-spectrum disorders and demonstrated that MMN impairments in such patients may worsen over time. Specifically, we found that young patients with the most impaired MMN amplitudes at baseline showed the most severe levels of disability at follow-up. Furthermore, in the subset of patients with repeat neurophysiological testing, central MMN was further impaired suggestive of neurodegenerative effects. MMN may serve as a neurophysiological biomarker to more accurately predict functional outcomes and prognosis, particularly at the early stages of illness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 46, 1 October 2013, Pages 161-169
نویسندگان
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