کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5845697 | 1561093 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation
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کلمات کلیدی
LBIPLP1PLPSNSCSt - CSTPMd - PMDProteolipid protein - Proteolipid پروتئینDynamic lung compliance - انطباق ریه پویاinterleukin - اینترلوکینPelizaeus-Merzbacher disease - بیماری Pelizaeus-Merzbachertumor necrosis factor–α - تومور نکروز عامل αCNS - دستگاه عصبی مرکزیPhase angle - زاویه فازsympathetic nervous system - سیستم عصبی سمپاتیکcentral nervous system - سیستم عصبی مرکزیParasympathetic nervous system - سیستم عصبی پاراسمپاتیکTNF-α - فاکتور نکروز توموری آلفاLung resistance - مقاومت ریهLung mechanics - مکانیک ریهPNS - کارمندان دولتCdyn - کدین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mice with Plp1 gene duplication model the most common form of Pelizaeus-Merzbacher disease (PMD), a CNS disease in which patients may suffer respiratory complications. We hypothesized that affected mice would lack airway responsiveness compared to wild-type and carrier mice during methacholine challenge. Wild-type (n = 10), carrier female (n = 6) and affected male (n = 8) mice were anesthetized-paralyzed, tracheostomized and ventilated. Respiratory mechanics were recorded at baseline and during escalating doses of nebulized methacholine followed by albuterol. Lung resistance (RL) was the primary endpoint. Lung tissues were assayed for inflammatory and histological differences. At baseline, phase angles were higher in carrier and affected mice than wild-type. Dose-response RL curves in affected and carrier mice indicated a lack of methacholine response. Albuterol reduced RL in wild-type and carrier, but not affected mice. Affected mice exhibited lower interleukin (IL)-6 tissue levels and alveolar inflammatory infiltrates. Affected and carrier mice, compared to wild-type, lacked airway reactivity during methacholine challenge, but only affected mice exhibited decreased lung tissue levels of IL-6 and inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 30, February 2015, Pages 22-31
Journal: Pulmonary Pharmacology & Therapeutics - Volume 30, February 2015, Pages 22-31
نویسندگان
Elena Rodriguez, Lauren Sakowski, Grace M. Hobson, Milena Hirata Armani, Portia A. Kreiger, Yan Zhu, Scott A. Waldman, Thomas H. Shaffer,