Excessive ethanol consumption under exposure to lead intensifies disorders in bone metabolism: A study in a rat model

► Exposure to lead (Pb) or/and ethanol (Et) disturbs bone metabolism in male rats. ► Et abuse under exposure to Pb increases the risk of bone damage. ► Excessive Et consumption decreases Pb accumulation in the skeleton. ► Destroying of the RANK/RANKL/OPG system is involved in interactive action of Pb and Et on bone.