Neuropathy target esterase (NTE): overview and future

► A brief overview of neuropathy target esterase (NTE) is presented. ► Toxicological data support NTE aging as the trigger for OP neuropathy. ► Conditional NTE knockouts and mutations result in neurodegeneration. ► NTE is a phospholipase: PNPLA6, nearly identical to insulin-regulated PNPLA7. ► Future research: is NTE regulated by insulin and involved in diabetic neuropathy?