کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5848429 | 1130156 | 2012 | 9 صفحه PDF | دانلود رایگان |

Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid peroxidation (LPO) as well as the ameliorative properties. Experimental diabetes was induced by a single intraperitoneal (i.p) injection of STZ (45Â mg/kg body weight (b.w.)) dissolved in 0.1Â mol/L citrate buffer (pH 4.5), 15Â min after the i.p administration of NA (110Â mg/kg b.w.). Diabetic rats exhibited increased plasma glucose with significant decrease in plasma insulin levels. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and the levels of low-molecular weight antioxidants vitamin C, vitamin E and reduced glutathione (GSH) were decreased while increases in the levels of LPO markers were observed in liver and kidney tissues of diabetic control rats as compared to normal control rats. Oral treatment with DS (100Â mg/kg/day) for a period of 45Â days showed significant ameliorative effects on all the biochemical parameters studied. Biochemical findings were supported by histological studies. These results indicated that DS has potential ameliorative effects in addition to its antidiabetic effect in type 2 diabetic rats.
Chemical structure of diosmin.Highlights⺠STZ-NA (streptozotocin-nicotinamide) generated oxidative damage in experimental diabetic rats. ⺠To evaluate the effect of DS in oxidative stress in STZ-NA-induced diabetic rats. ⺠The administration of DS can be effective in inhibiting oxidative stress. ⺠We conclude that DS has potential antioxidant and ameliorative effect in STZ rats.
Journal: Chemico-Biological Interactions - Volume 195, Issue 1, 5 January 2012, Pages 43-51