Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways

► Combined treatment increased cytotoxicity and apoptotic cell death in HL-60 cells. ► Combined treatment induced apoptosis through activation of JNK and p38 MAPK. ► Combined treatment could be a potential therapeutic strategy against leukemia.