کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856263 | 1131972 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Five-year yield variation in N-nitrosonornicotine and (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone from the smoke of commercial cigarette brands on the Japanese market
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کلمات کلیدی
RSDTSNAsHCIN-nitrosonornicotineNNNNNKTPMrelative standard deviation - انحراف استاندارد نسبیISO - ایزوHealth Canada Intense - بهداشت کانادا شدیدVariation - تغییرCigarette smoke - دود سیگارtotal particulate matter - ذرات جامدInternational Organization for Standardization - سازمان بین المللی استاندارد سازیcarbon monoxide - منوکسیدکربنTobacco-specific nitrosamines - نیتروزامین های خاص توتونJapan - ژاپن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study reports on variation in the yields of N-nitrosonornicotine (NNN) and (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) from the mainstream smoke of cigarette brands and describes factors affecting this variation. Yields of NNN and NNK from smoke and tobacco filler, which is blended and cut tobacco filled in a cigarette tube, together with cigarette design parameters, were measured for 11 commercial cigarette brands, which were available in Japan from 2009 to 2013. The ranges of the relative standard deviations (RSDs) for NNN from the smoke of each brand were 5.0%-29.9% under International Organization for Standardization (ISO) and 6.3%-26.3% under Health Canada Intense (HCI) smoking regime. When these RSDs were compared with those of tar, nicotine, and carbon monoxide yields in each brand, they were found to be much higher for all of the brands under the HCI, and higher for most of the brands under the ISO smoking regime. In addition, the RSDs of NNN and NNK in smoke were mostly higher than those of KY3R4F which was manufactured in a single batch. It was identified that variation in NNN yields from tobacco filler mainly contribute to variation in NNN yields from smoke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 3, December 2015, Pages 953-959
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 3, December 2015, Pages 953-959
نویسندگان
T. Hyodo, K. Minagawa, A. Mikita,