کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858064 1562161 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats
چکیده انگلیسی


- Simvastatin and its metabolite Simvastatin β-hydroxy acid were investigated in-vitro and in rats.
- Simvastatin and its metabolite decrease progestagen production in-vitro.
- Simvastatin decreased progestagens in gonads, brain and plasma from rats.
- Simvastatin affected the HPG-axis by decreasing plasma FSH.

Endocrine modulating effects of Simvastatin (SV) and its metabolite, Simvastatin β-hydroxy acid (SVA), were investigated in H295R cells and in female Sprague-Dawley (SPRD) rats. H295R cells were exposed to SV and SVA concentrations from 0 to 10 μM for 48 h. Four groups of SPRD rats received 0 (CT), 1.3 (L), 5.0 (M), and 20.0 (H) mg SV/kg bw/day for 14 days. 10 Steroids were investigated in H295R growth media, and in tissues and plasma from rats using GC-MS/MS. Plasma LH and FSH were quantified by ELISA. In the H295R assay, SV and SVA particularly decreased progestagens with IC50-values from 0.10-0.13 μM for SV and from 0.019-0.055 μM for SVA. In rats, SV decreased progestagens in ovaries, brain and plasma, and plasma FSH in the M (72.4% decrease) and H group (76.6% decrease). Because progestagens and gonadotropins are major players in fertility, administration of SV might exert negative effects on female reproduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 58, December 2015, Pages 174-183
نویسندگان
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