Epigenetic dimension of oxygen radical injury in spermatogonial epithelial cells

- Effect of isocyanate exposure on male germ line genome is relatively unknown.
- Isocyanates induce functional derailment of spermatogonial mitochondria machinery.
- The mitochondrial retrograde signalling triggers aberrant chromatin regulation.
- This redox-dependent epigenomic imbalance causes genomic unsteadiness.