کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5859220 | 1562336 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung
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کلمات کلیدی
CDC42DVL1IRX4BCMO1CTHRC1KIF11AEBP1BEAS-2BFOXM1ATF2FDRRac1RhoAHCC - HCCβ-carotene - β-کاروتنEnrichment Score - امتیاز غنی سازیBeta-carotene - بتاکاروتنforkhead box M1 - جعبه جعبه M1Gene silencing - خاموشی ژنDAVID - دیویدRas-related C3 botulinum toxin substrate 1 - زیر بغل سم بوتولینوم C3 مرتبط با ریز 1Lung cancer - سرطان ریهcell division cycle 42 - سلول تقسیم سلولی 42Ras homolog gene family member A - عضو خانواده خانواده ژن رای همولوگactivating transcription factor 2 - فعال کردن عامل رونویسی 2Gene ontology - هستیشناسی ژنیDatabase for Annotation Visualization and Integrated Discovery - پایگاه داده برای تجسم خلاصه و یکپارچه کشفJun - ژوئنHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung](/preview/png/5859220.png)
چکیده انگلیسی
β-Carotene (BC) is omnipresent in our diet, both as natural food component as well as an additive. BC and its metabolites have important biological functions. For this reason, BC is generally considered to be a health promoting compound. Two human trials, however, have described adverse effects in lung tissue, increasing the risk of lung cancer. We previously applied transcriptomic analyses in a unique animal model, beta-carotene 15,15â²-monooxygenase 1 knockout (Bcmo1â/â) mice that are, like humans, able to accumulate intact BC. In our search to unravel the molecular action of BC in the lung, we previously identified two genes particularly strongly down-regulated by BC in lung tissue of the male Bcmo1â/â mice: frizzled homologue 6 (Fzd6) and collagen triple helix repeat containing 1 (Cthrc1). In the present study, our aim was to further elucidate the role of FZD6 in lung epithelial cells and to provide a mechanistic explanation for BC increased lung cancer risk in humans. We performed whole genome microarray analysis on silenced FZD6 in non-tumor human type II bronchial epithelial BEAS-2B cells using RNAi. To directly link FZD6 to BC-effects on the lung, we compared the FZD6-silenced BEAS-2B gene expression profile to the BC-dependent gene expression profile of Bcmo1â/â mouse lungs. A number of relevant genes were regulated in the same direction in FZD6â BEAS-2B and in BC-exposed lungs of Bcmo1â/â mice and revealed enrichment of the Gene Ontology terms “oncogenes”, “cell proliferation” and “cell cycle”, which suggests a mediating role of FZD6 in BC-induced uncontrolled proliferation of lung cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 320, 5 June 2014, Pages 67-73
Journal: Toxicology - Volume 320, 5 June 2014, Pages 67-73
نویسندگان
Rosaria Piga, Dorien van Dartel, Annelies Bunschoten, Inge van der Stelt, Jaap Keijer,