In vitro skin penetration of fragrances: Trapping the evaporated material can enhance the dermal absorption of volatile chemicals

► The article describes an in vitro study of the evaporation and skin absorption of fragrances. ► Evaporation rates measured on skin and on synthetic substrates differ significantly. ► Trapping chambers can hinder the evaporation of volatiles and enhance their dermal absorption. ► These effects distort the risk assessment of fragrances and lead to unrealistic margins of safety.