کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5904476 | 1158002 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Soy protein is beneficial but high-fat diet and voluntary running are detrimental to bone structure in mice
ترجمه فارسی عنوان
پروتئین سویا مفید است، اما رژیم غذایی با چربی زیاد و کار داوطلبانه برای ساختن استخوان در موش ها زیان آور است
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کلمات کلیدی
cortical area fractionSPICt.Ar/Tt.ArWAPConn.DBMDWMLCt.ArCt.ThTb.NTb.SpTb.ThBV/TV - BV / TVBone - استخوان Tartrate-resistant acid phosphatase 5b - اسید فسفاتاز 5b مقاوم در برابر تارتاتconnectivity density - تراکم اتصالBone mineral density - تراکم معدنی استخوانtrabecular separation - جداسازی ترابکولارSoy protein isolate - جدایی پروتئین سویاBone volume - حجم استخوانTotal Volume - حجم کلrunning - در حال اجراSoy - سویاtrabecular number - شماره تراککالtrabecular thickness - ضخامت تراککالcortical thickness - ضخامت قشرCortical bone area - منطقه استخوان کورتیکMice - موشFat - چربیBone volume fraction - کسر حجم استخوان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Physical activity and soy protein isolate (SPI) augmentation have been reported to be beneficial for bone health. We hypothesized that combining voluntary running and SPI intake would alleviate detrimental changes in bone induced by a high-fat diet. A 2 Ã 2 Ã 2 experiment was designed with diets containing 16% or 45% of energy as corn oil and 20% SPI or casein fed to sedentary or running male C57BL/6 mice for 14 weeks. Distal femurs were assessed for microstructural changes. The high-fat diet significantly decreased trabecular number (Tb.N) and bone mineral density (BMD) and increased trabecular separation (Tb.Sp). Soy protein instead of casein, regardless of fat content, in the diet significantly increased bone volume fraction, Tb.N, connectivity density, and BMD and decreased Tb.Sp. Voluntary running, regardless of fat content, significantly decreased bone volume fraction, Tb.N, connectivity density, and BMD and increased Tb.Sp. The high-fat diet significantly decreased osteocalcin and increased tartrate-resistant acid phosphatase 5b (TRAP 5b) concentrations in plasma. Plasma concentrations of osteocalcin were increased by both SPI and running. Running alleviated the increase in TRAP 5b induced by the high-fat diet. These findings demonstrate that a high-fat diet is deleterious, and SPI is beneficial to trabecular bone properties. The deleterious effect of voluntary running on trabecular structural characteristics indicates that there may be a maximal threshold of running beyond which beneficial effects cease and detrimental effects occur. Increases in plasma osteocalcin and decreases in plasma TRAP 5b in running mice suggest that a compensatory response occurs to counteract the detrimental effects of excessive running.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 35, Issue 6, June 2015, Pages 523-531
Journal: Nutrition Research - Volume 35, Issue 6, June 2015, Pages 523-531
نویسندگان
Lin Yan, George L. Graef, Forrest H. Nielsen, LuAnn K. Johnson, Jay Cao,