کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905543 | 1159908 | 2015 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats
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کلمات کلیدی
terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labelingVit ENF-κBTOScyt-cFRAPSTZOSIGSETAS - IASROS - ROSstreptozotocin - استرپتوزوتوسینDiabetes - بیماری قندOxidative stress - تنش اکسیداتیوferric reducing ability of plasma - توانایی کاهش آهن در پلاسماtumor necrosis factor-α - تومور نکروز عامل αTUNEL - تونلApoptosis - خزان یاختهایcytochrome c - سیتوکروم سیOxidative stress index - شاخص استرس اکسیداتیوGrape seed extract - عصاره دانه انگورTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappaB - فاکتور هسته ای kappaBHippocampus - هیپوکامپ Total antioxidant status - وضعیت آنتی اکسیدان کلtotal oxidant status - وضعیت کل اکسیدانVitamin E - ویتامین E
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We aimed to investigate the effects of grape seed extract (GSE) and vitamin E (Vit E) on oxidative stress and apoptosis in the hippocampus of streptozotocin-induced diabetic rats. In Control, Diabetic, and Diabetic treated with GSE (Diabetic + GSE) and vitamin E (Diabetic + Vit E) groups, oxidative stress index (OSI), TUNEL staining and Bcl-2, Bcl-XL, Bax, caspase-3, -9, and -8, Cyt-c, TNF-α, and NF-κB gene expressions were evaluated. OSI was significantly increased in the plasma and hippocampus of the Diabetic compared to Control group and decreased in Diabetic + GSE and Diabetic + Vit E groups compared to Diabetic. TUNEL positive neurons significantly increased in the hippocampus of the Diabetic group compared to Control and decreased in Diabetic + GSE (more prominently) and Diabetic + Vit E groups compared to Diabetic. In the hippocampus of the Diabetic group, Bcl-2 and Bcl-XL gene expressions were significantly decreased; Bax, caspase-3, -9, and -8, Cyt-c, TNF-α, and NF-κB gene expressions were significantly increased compared to Control. In Diabetic + GSE and Diabetic + Vit E groups, Bcl-2 gene expressions were significantly increased; Bcl-XL gene expressions did not differ compared to the Diabetic group. The expression of Bax, caspase-3, -9, and -8, Cyt-c, TNF-α, and NF-κB genes in the Diabetic + GSE group and the expression of caspase-3 and -9, TNF-α, and NF-κB genes in the Diabetic + Vit E group were significantly decreased compared to Diabetic. In conclusion, GSE (more prominently) and vitamin E decreased oxidative stress and neuronal apoptosis occurring in the hippocampus of diabetic rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 555, Issue 2, 25 January 2015, Pages 119-126
Journal: Gene - Volume 555, Issue 2, 25 January 2015, Pages 119-126
نویسندگان
Goksin Nilufer Yonguc, Yavuz Dodurga, Esat Adiguzel, Gulsah Gundogdu, Vural Kucukatay, Seda Ozbal, Ismail Yilmaz, Ulker Cankurt, Yusuf Yilmaz, Ilgaz Akdogan,