کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5913025 | 1161853 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
The human transcriptome comprises >80Â 000 protein-coding transcripts and the estimated number of proteins synthesized from these transcripts is in the range of 250Â 000 to 1 million. These transcripts and proteins are encoded by less than 20Â 000 genes, suggesting extensive regulation at the transcriptional, post-transcriptional, and translational level. Here we review how RNA sequencing (RNA-seq) technologies have increased our understanding of the mechanisms that give rise to alternative transcripts and their alternative translation. We highlight four different regulatory processes: alternative transcription initiation, alternative splicing, alternative polyadenylation, and alternative translation initiation. We discuss their transcriptome-wide distribution, their impact on protein expression, their biological relevance, and the possible molecular mechanisms leading to their alternative regulation. We conclude with a discussion of the coordination and the interdependence of these four regulatory layers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Genetics - Volume 31, Issue 3, March 2015, Pages 128-139
Journal: Trends in Genetics - Volume 31, Issue 3, March 2015, Pages 128-139
نویسندگان
Eleonora de Klerk, Peter A.C. 't Hoen,