Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

► KU-32 is a C-terminal Hsp90 inhibitor that improves physiological indices of DPN. ► Weekly KU-32 therapy significantly increased intra-epidermal nerve fiber density. ► Diabetes decreased and KU-32 improved sensory neuron mitochondrial function. ► Enhanced mitochondrial bioenergetics may contribute to the efficacy of KU-32.