کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6051177 | 1583311 | 2014 | 8 صفحه PDF | دانلود رایگان |
ObjectiveThe aim of this study was to investigate the neoplastic potential of the PA of minor oral salivary glands measured by apoptosis (Bcl-2, Bax and p53), mucosecretory activity (MUC1), and cellular proliferation (Ki-67).DesignThirty-one cases of PA of the oral cavity and four controls (C) taken from normal oral minor salivary glands were analyzed using the immunohistochemistry technique. The proteins were detected utilizing a semi-quantitative method (scores) as follows: (â) negative â¤5%, (+) low 6-25%, (++) moderate 26-50% and (+++) high >50% of positive tumour cells. The apoptotic indices were evaluated by the ratio Bcl-2/Bax. Non-parametric comparison and correlation tests were used for analysis.ResultsThe data showed high staining of anti-apoptotic protein Bcl-2 in both groups (PA = 57.9%; C = 67.7%) and a significantly lower expression of pro-apoptotic protein Bax (PA = 22.7%; C = 97.7%) and MUC1 (PA = 14%; C = 82.3%) in PA than in C (p < 0.001). On the other hand, a similar expression of Ki-67 and p53 proteins (â¤5%) was seen in both PA and C. In PA, only 2/31 cases showed the ratio Bcl-2/Bax < 1.There was no difference in cellular expression with regard to clinical variables or clinical outcome (p > 0.05).ConclusionThe neoplastic potential of PA could be associated with an imbalance in apoptotic processes and a lower index of cellular proliferation. Mucosecretory activity does not play a significant role in primary PA.
Journal: Archives of Oral Biology - Volume 59, Issue 6, June 2014, Pages 578-585