Effect of PGE2 induced by compressive and tensile stresses on cementoblast differentiation in vitro

► We evaluated the role of PGE2 induced by compressive stress (CS) and tensile stress (TS) on cementoblast metabolism in vitro. ► CS and TS enhanced COX-2 mRNA expression and PGE2 production. ► Genes related to mineral metabolism were also enhanced by mechanical stimulation on an endogenous PGE2-mediated manner. ► It is shown that PGE2 plays an important role on mediating cementoblast mechanosensitivity.