The optimal dose of recombinant human osteogenic protein-1 enhances differentiation of mouse osteoblast-like cells: An in vitro study

These results suggest that cell proliferation of MC3T3-E1 is depended on culture time and rhOP-1 concentration, rhOP-1 could stimulate the differentiation of MC3T3-E1 cells and the optimal concentration could be 200 ng/ml.