کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6069614 1587508 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DermatopathologyHistopathologic characteristics of scleromyxedema: A study of a series of 34 cases
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
DermatopathologyHistopathologic characteristics of scleromyxedema: A study of a series of 34 cases
چکیده انگلیسی

BackgroundFew histologic studies describe the histopathologic aspects of scleromyxedema.ObjectiveWe sought to describe the histopathologic and immunohistochemical features of scleromyxedema in a large series of patients.MethodsWe studied all the cases with scleromyxedema diagnosed between 2000 and 2014 at participating centers. Sections with hematoxylin-eosin and special stains were examined. Immunohistochemistry for CD3, CD4, CD8, CD20, CD68, and factor XIIIa was performed in 10 cases.ResultsA total of 44 skin biopsy specimens from 34 patients were reviewed. Two different histopathologic patterns were observed: the classic microscopic triad (dermal mucin deposition, fibroblast proliferation, fibrosis) was identified in 34 specimens, whereas an interstitial granuloma annulare-like pattern was found in 10 specimens. A superficial perivascular infiltrate with T lymphocytes was found in all specimens whereas an interstitial proliferation of CD68+ epithelioid cells was identified in the 10 specimens with an interstitial granuloma annulare-like pattern. Elastic fibers were largely lost, explaining the redundant folds of the disease.LimitationsThis was a retrospective study.ConclusionsScleromyxedema shows 2 histopathologic patterns, including the classic type with the microscopic triad of mucin, fibroblast proliferation and fibrosis, and an interstitial granuloma annulare-like pattern. Recognition of these histologic presentations expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition in the absence of a clinicopathological correlation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 74, Issue 6, June 2016, Pages 1194-1200
نویسندگان
, , , , , , , , , , ,