کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074509 | 1203487 | 2016 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin
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کلمات کلیدی
EDCTBHQNrf2tert-butylhydroquinoneLKOFLGkeap1 - buy1LOR - آنهاNF-E2-related factor 2 - عامل NF-E2 2filaggrin - فیلهگرینLoricrin - لوریکینEpidermal differentiation complex - مجتمع تمایز اپیدرمالwild type - نوع وحشیcornified cell envelope - پاکت نامه سلولی ذرتKelch-like ECH-associated protein 1 - پروتئین مرتبط با ECH کلچ 1
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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چکیده انگلیسی
Loricrin is a major component of the cornified cell envelope, a highly insoluble structure composed of covalently cross-linked proteins. Although loricrin knockout mice only exhibit a mild transient phenotype at birth, they show a marked delay in the formation of an epidermal barrier in utero. We recently discovered that induction of a compensatory response to repair the defective barrier is initiated by amniotic fluid via activation of NF-E2-related factor 2 and identified Sprr2d and Sprr2h as direct transcriptional targets. Proteomic analysis suggested that other proteins were also incorporated into the loricrin knockout cell envelope, in addition to the small proline rich proteins. Here we present evidence suggesting that the late cornified envelope 1 proteins are also compensatory components as determined by their localization within the loricrin knockout cell envelope via immunoelectron microscopy. We also demonstrate that late cornified envelope 1 genes are upregulated at the transcriptional level in loricrin knockout mouse skin and confirm that late cornified envelope 1 genes are transcriptional targets of NRF2. Our present study further highlights the complexity and importance of a compensatory mechanism that evolved in terrestrial animals to ensure the formation of a functional epidermal barrier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 8, August 2016, Pages 1656-1663
Journal: Journal of Investigative Dermatology - Volume 136, Issue 8, August 2016, Pages 1656-1663
نویسندگان
Yosuke Ishitsuka, Aaron J. Huebner, Robert H. Rice, Peter J. Koch, Vladislav V. Speransky, Alasdair C. Steven, Dennis R. Roop,