کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074776 | 1203488 | 2016 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice
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کلمات کلیدی
LPSFOXP3TNCBGATA-3RORγtSEAPNPTT helperIKKTreg2,4,6-trinitrochlorobenzene - 2،4،6-ترنیتروکلروبروزنIκB kinase - IkB kinaseT-box expressed in T cells - T-box در سلول های T بیان می شودSecretory alkaline phosphatase - آلکالین فسفاتاز مخلوطSTAT - آمارT-bet - تی شرط بندیforkhead box P3 - جعبه جعبه P3Atopic dermatitis - درماتیت آتوپیکRegulatory T cell - سلول T تنظیم کنندهNeomycin phosphotransferase - فوموتانسفراز نئومیسینlipopolysaccharide - لیپوپلی ساکاریدSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیGATA binding protein 3 - پروتئین گیرنده GATA 3
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice](/preview/png/6074776.png)
چکیده انگلیسی
T-cell-mediated immune responses play an important role in body protection. However, aberrantly activated immune responses are responsible for inflammatory and autoimmune diseases. The regulation of pathologic immune responses may be a potential therapeutic strategy for the treatment of these diseases. Despite that multiple pharmacologic properties of benzoxathiole derivatives have been defined, the molecular mechanisms underlying these properties remain to be clarified. Here, we demonstrated the benzoxathiole derivative 2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one (BOT-4-one) regulated immune responses and ameliorated experimentally induced inflammatory skin diseases both in vitro and in vivo. BOT-4-one inhibited the differentiation of CD4+ T-cell subsets by regulating the expression and production of T-cell lineage-specific master transcription factors and cytokines and activating the signal transducer and activator of transcription proteins. In addition, BOT-4-one inhibited TCR-mediated Akt and NF-κB signaling. Topical application of BOT-4-one ameliorated experimentally induced inflammatory skin diseases in mice models such as 2,4,6-trinitrochlorobenzene-induced contact and atopic dermatitis and IL-23-induced psoriasis-like skin inflammation. Our study demonstrated that BOT-4-one ameliorates inflammatory skin diseases by suppressing the pathogenic CD4+ T cell differentiation and overall immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 1, January 2016, Pages 107-116
Journal: Journal of Investigative Dermatology - Volume 136, Issue 1, January 2016, Pages 107-116
نویسندگان
Hyun Gyu Lee, Nam-chul Cho, Ae Jin Jeong, Yu-Chen Li, Sung-Ja Rhie, Jung Sook Choi, Kwang-Ho Lee, Youngsoo Kim, Yong-Nyun Kim, Myoung-Hwan Kim, Ae Nim Pae, Sang-Kyu Ye, Byung-Hak Kim,