کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6075352 1203498 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review ArticleSkin Disease in Laminopathy-Associated Premature Aging
ترجمه فارسی عنوان
نقص مقاله بیماری پوستی در پیری زودرس لامینوپاتی مرتبط است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی

The nuclear lamina, a protein network located under the nuclear membrane, has during the past decade found increasing interest due to its significant involvement in a range of genetic diseases, including the segmental premature aging syndromes Hutchinson-Gilford progeria syndrome, restrictive dermopathy, and atypical Werner syndrome. In this review we examine these diseases, some caused by mutations in the LMNA gene, and their skin disease features. Advances within this area might also provide novel insights into the biology of skin aging, as recent data suggest that low levels of progerin are expressed in unaffected individuals and these levels increase with aging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 135, Issue 11, November 2015, Pages 2577-2583
نویسندگان
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